FDA approves JOURNAVX drugs to treat pain without poisoning.

The Food Pharmaceutical Bureau has approved a new drug on Thursday to treat injuries and pain from surgery. It is expensive and has a price of $ 15.50 per pill. However, unlike opioid analgesics, it is not addictive.

This is because the drugs made by pharmaceuticals and sold as JOUNGRAVX function only in the nerve outside the brain and block pain signals. I can't enter the brain.

Researchers expect the first generation of new generations of more powerful non -member drugs to relieve pain.

In order to test this medicine, the peak of Boston conducted two large -scale clinical trials, each with about 1,000 patients who felt pain in surgery. They were randomly assigned to get placebo. Opioids are sold as Vicodin, a combined painful drug that is widely used by acetaminophen (Tylenol) and hydrocodon. Or get the suzetrigin.

In one exam, the patient had abdominal plastic surgery or tummy tacks. On the other hand, there was a surgery for the aponeurosis. The side effects of the suzetrigin reported by the patient were similar to those reported by patients taking placebo.

The company also submitted data from 250 research, which evaluated the safety and patients of patients with pain in surgery, trauma, or accidents.

Susetrygin has relieved the pain as much as the combination of opioids. Both were better than the Plasebo, which relieves the pain.

However, the price of Susetrygin is much higher than the price of acetaminophen and hydrocodon. Patients are expected to take 2 tablets a day for a total cost of $ 31 a day. Old drugs said Dr. John D. Roses, a specialist in the Honorary Pain at Washington, stated that it was “cheap” and “cheap.”

However, there are no unpleasant side effects of opioids such as nausea and drowsiness, which is not illegal.

“If you have an opioid, there are many people who want opioids constantly,” said Roser.

Dr. David Altshurer, the highest science officer at the top, said that about 85,000 people became addicted annually after taking prescription opioids. It is a small percentage of 40 million prescription opioids every year for surgery, accidents, or trauma acute pain, but still many.

The story of the Suzetrigin began in the late 1990s with basic research by Dr. Steven Wax Man in Yale. He was wondering how neurological cells convey pain to their brains.

Nerve cells have nine sodium channels (small molecular cells) that generate electrical signals.

However, he discovered that two of these channels were only active outside the brain. Dr. Waxman said that one called NAV1.7 was like a firecracker fuse. Nerve cells activate NAV1.7. The signal activates the second channel NAV1.8. It said that it sends a pain electrical signal to the brain.

Drugs that can block NAV1.7 or NAV1.8 seemed to be a powerful painkiller with no toxic because it does not affect the brain. (Dr. Waxman is not paid by the top, but we are consulting with other companies that are working on similar drugs.)

However, there was another part of the puzzle. Did these labs be applied to humans?

If the lab's work is predictive, people with a constant mutation generated by NAV1.7 or NAV1.8 will be constantly painful. And the people with the opposite mutation -those who block the channel -should not feel pain.

It is very rare if there is a variety of either.

Dr. Waxman contacted a doctor with pain in the Northern Hemisphere as a whole, asking if there was a certain painful pain that could be caused by an excessive mutation of NAV1.7 or NAV1.8. 。 He appeared empty -handed.

Later, in 2004, the Ellislomelalgi Association talked about Alabama's family, where members are suffering from pain. Most people were absorbed in opioids and couldn't go to school or work. Their condition was called “Man on Fire Syndrome”.

Dr. Waxman and his colleagues discovered that this family member had a mutation on the NAV1.7 channel, and the pain was constantly ignited.

Another researcher reported that the Pakistani family, who felt painful, felt that the same channel had a mutation that blocked the firing. The people walked on the hot coal and felt nothing, so they called them the firewalcar.

Vertex's new drugs that block the NAV1.8 channel are very specific. Other sodium channels are left as they are. When people stop taking tablets, the effects of the suzetrigin disappear.

However, people with acute pain may need such a medicine, but there are other groups that need to alleviate pain, but have few good options. Those who have damaged the nerves that cause certain pain, called peripheral neuropathic pain. The group contains people with diabetes that can hurt or paralyze hands and feet in other symptoms. It also includes people with the primeval disorders of the pulmonary skin or the pinch in the spine. Sciatica is a form of this state.

In a small study, the peak has found that the sedience has helped people with diabetic neuropathy, but not better than the placebo of those who are pinching the spinal nerve.

However, Dr. Altshurer said that the company is conducting large -scale research in both patients. Analysts and researchers thought that they were disappointed with patients with nerves between thorns, but there were no approved drugs for painful conditions, and drugs were safe. The company decided to proceed because the mechanism was very clear. “

“No one has helped these 4 million,” he said.